News

2019

July 14
First flu infections determine susceptibility throughout life, and potentially vaccine effectiveness. New preprint by Phil (and a parallel study by Katie Gostic, who joins the lab this fall).
July 1
Our R01 to model the longitudinal development of immunity to influenza (with collaborator Aubree Gordon at U. Michigan) begins!
June 20
We say good-bye to Ed, who is heading off to found his own startup to save us from Facebook and all the rest. His statistical and programming advice will live on in our models forever.
April 10
Our paper in Nature Communications shows how immune memory shapes protection to influenza in adults and children. Bonuses: Estimation of imprinting effects, epidemic sizes, household transmission, & more!
March 8
Angsty germophobia and germophilia on display in this Nerdette podcast.

2018

September 18
We find evidence of some vaccine-induced evolution in flu.
June 29
Sarah eventually checks her text messages and discovers she has been awarded tenure!
June 26
Our special issue of Immunological Reviews, "Characterization of the Immunological Repertoire", hits the stands.
June 1
Ed returns to the fold to model the development of immunity to flu. True to form, he immediately proposes provocatively simple models. It's good to have him back!
May 25
Sylvia, Sarah, and collaborators statistically model serological data and find differences in the dynamics of influenza immunity between children and adults.
May 21
Sarah and Joe Lewnard describe the challenges of understanding how the influenza vaccine's effectiveness varies with individuals' histories of exposure to flu.
May 17
Congratulations to Frank on his successful PhD defense! We are happy to have him around another few months before he returns to medical school.
May 10
Marcos has been awarded a William Rainey Harper Fellowship, one of the University of Chicago's highest honors. Congratulations, Marcos!
April 27
Congratulations to Sylvia for successfully defending her PhD thesis!
February 16
Marcos, Sarah, and collaborators had a paper accepted for publication in Molecular Biology and Evolution showing that mutability losses in long-lived B cell lineages are intrinsic to the neutral and adaptive evolution of B cell populations.
February 5
Sarah and collaborators had a paper accepted for publication in Clinical Infectious Diseases showing that low H3N2 vaccine efficacy in 2012-2013 may have been due to the emergence of antigenically novel influenza strains, and not due to a failure of the egg-adapted strain to induce an immune response to the intended vaccine strain.

2017

December 5
Sylvia, Sarah, Greg Dwyer, and collaborators published a paper in PNAS showing that the high prevalence of HPV in men can be explained by repeated or sustained infections with ecologically distinct HPV types.
November 11
Kangchon, Sarah, and collaborators published a paper in PNAS showing that a glycosylation site in contemporary H3N2 viruses alters antibody binding by egg-adapted vaccine strains.
October 6
Phil Arevalo joins the lab as a postdoctoral researcher. Welcome, Phil!
July 17
Marcos and Sarah find loss of mutability in long-lived B cell receptor sequences.
July 14
Frank and Sarah, in collaboration with Anup Malani (University of Chicago Law School), examine the impact of vaccines on the evolution of seasonal influenza and the associated implications for public health policy.
July 11
Sarah and collaborators find evidence that low seasonal influenza vaccine effectiveness in 2012-13 was not caused by egg-adaptative mutations.
July 8
Sarah and Ed's paper on the coexistence of drug-sensitive and drug-resistant pneumococcus strains is in preprint at the Journal of the Royal Society Interface.
June 1
Rohan Dandavati and Graham Northrup join the Cobey lab. Welcome!
April 20
Sarah and Ed examine the coexistence of drug-sensitive and drug-resistant pneumococcus strains.
April 17
Kangchon Kim joins the lab as a postdoc! Welcome, Kangchon!
January 23
Scott Hensley and Sarah propose that many patterns in influenza immunology make sense in light of original sin.
January 12
Rahul is interviewed on Chicago's public radio station about his recent PLOS Computational Biology paper!

2016

December 28
Sarah and Ed's paper on the challenges of causal inference with CCM has been published.
December 15
Sylvia was awarded an NIH F30 grant. Congratulations, Sylvia!
September 14
Frank and Sarah's paper on the phylogeography of influenza (in collaboration with Trevor Bedford) was published in Proceedings B and featured in a Science Life article.
May 12
Frank and Marcos both successfully defended their dissertation proposals this week and are now PhD candidates. Congratulations!
April 18
Sarah gives a seminar in the NYU Department of Biology.
January 6
Sarah and Ed's new paper shows that causal inference using state-space reconstruction is unreliable in natural systems.

2015

December 10
Daniel Zinder joins the lab as a postdoc! Welcome, Daniel!
December 1
Colin Kyle joins the lab as a research programmer. Welcome, Colin!
November 27
Sarah was interviewed on NPR about influenza's phylogeography and its coevolution with the immune system.
September 14
Rahul Subramanian begins his PhD in the lab!
July 20
Sarah teaches a 2.5-day course on "Pathogen evolution, selection, and immunity" with Trevor Bedford at the Statistics and Modeling in Infectious Diseases (SISMID) summer school in Seattle.
July 20
Publication of theme issue, "The dynamics of antibody repertoires" of the Philosophical Transactions of the Royal Society B
July 8
Sarah talks at the Forecasting Evolution? conference in Lisbon.
June 22
Frank Wen begins his PhD in the lab!
June 15
Lev Tsypin, a third year undergraduate, begins his summer rotation in the lab! He'll be working with Igor on fitting nonlinear dynamics.
May 14
Igor Vasiljevic joins the lab to investigate methods to fit stochastic, nonlinear dynamical models.
March 23
Our special issue on microbial resistance is published in Evolutionary Applications.
March 22
Sarah co-chairs a special session on systems immunology at the Keystone Symposium on the Golden Anniversary of B Cell Discovery.
March 19
Sarah presents at the RAPIDD workshop "Modeling and predicting influenza phenotypes" at Cambridge University.

2014

December 1
Congratulations to Sylvia for successfully defending her thesis proposal!
November 29
Congratulations to Marcos, whose paper has just been published in Ecology Letters!
November 24
Sarah and Fred Wulczyn receive a seed grant from the University of Chicago's BIG Ideas Generator to test methods of state-space reconstruction.
November 18
Sarah talks at the Center of the Study of Biodiversity in Amazonia's thematic school, "Advanced methods and applications in ecology, evolution, and control of infectious diseases".
October 6
Sarah receives the NIH New Innovator Award, which provides five years of support for the project "Modeling the Evolutionary Dynamics of Immunity to Influenza for Vaccine Development"
September 15
Welcome to Marcos Vieira, who begins his PhD studies in our lab!
July 17
Our new paper argues that pathogens evolve in a more complex immune environment than most models assume, and the differences matter.
June 26
Sarah and Patrick Wilson (co-PI) receive the McDonnell Foundation's Studying Complex System Scholar Award for "Measuring the predictability of evolution through adaptive immunity."
May 5
The third meeting of our NESCent working group takes place in Durham, NC.
May 1
Congratulations to Frank, who'll be starting at the University of Chicago's MD/PhD program this summer!
April 2
Sarah gives a talk at the Jacques Monod conference on viral evolution in Roscoff, France.
January 27
The second meeting of our NESCent working group takes places in Durham, NC.

2013

December 11
Sarah gives a talk at the J. Craig Venter Institute.
November 4
The first meeting of our NESCent working group takes place in Durham, NC.
October 14
Collaborator Lauren Childs visits from HSPH.
October 14
Sarah and Jack Gilbert receive a $75,000 seed grant from the DoE to develop methods to infer pathogen interactions.
October 4
Sarah gives a talk at Swarthmore.
August 20
Sarah co-chairs a symposium on the evolution and genetics of drug resistance at the European Society of Evolutionary Biology conference in Lisbon, Portugal.
August 12
Sylvia Ranjeva begins her rotation in the lab! She'll be working on a HPV project she started with Greg Dwyer.
July 17
Frank Wen joins the lab to work on the phylogeography of influenza!

 

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