We study how the host adaptive immune response coevolves with pathogens, especially in ways relevant to vaccine design and pathogen diversity. Our work is computational, and we collaborate closely with immunologists and epidemiologists.
First flu infections determine susceptibility throughout life, and potentially vaccine effectiveness. New preprint by Phil (and a parallel study by Katie Gostic, who joins the lab this fall).
July 14, 2019
Age-specific differences in the dynamics of protective immunity to influenza in Nature Communications (2019)
Influenza virus vaccination elicits poorly adapted B cell responses in elderly individuals in Cell Host & Microbe (2019)
Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination in The Journal of Clinical Investigation (2018)