We study how the host adaptive immune response coevolves with pathogens, especially in ways relevant to epidemiological and evolutionary forecasting, vaccine design, and pathogen diversity. Our work is computational, and we collaborate closely with immunologists and epidemiologists.
Sarah weighs in on the new evidence for market origins in the New York Times.
March 18, 2023
In collaboration with the US Flu Vaccine Effectiveness Network and researchers at the CDC and Harvard School of Public Health, we report that repeat vaccination effects cannot be fully explained by clinical infection history or differences in the timing of vaccination between people---but influenza infections that are not medically attended might explain this puzzling phenomenon.
March 17, 2023
Germline-encoded specificities and the predictability of the B cell response in PLOS Pathogens (2023)
Evaluating reduced effectiveness after repeat influenza vaccination while accounting for confounding by recent infection and within-season waning in medRxiv (2023)
Investigation of impact of childhood immune imprinting on birth year-specific risk of clinical infection during influenza A virus epidemics in Hong Kong in The Journal of Infectious Diseases (2023)
Getting the most out of noisy surveillance data in Nature Computational Science (2022)