We study how the host adaptive immune response coevolves with pathogens, especially in ways relevant to epidemiological and evolutionary forecasting, vaccine design, and pathogen diversity. Our work is computational, and we collaborate closely with immunologists and epidemiologists.
Lauren McGough discusses her research goals around understanding dynamical patterns of pathogen evolution at the National Institute for Theory and Mathematics in Biology, Research-in-Progress series.
Aug. 13, 2024
Congratulations to Daniel (Sang Woo) on being awarded a highly competitive LSRF fellowship!
Aug. 1, 2024
Vaccination against rapidly evolving pathogens and the entanglements of memory in Nature Immunology (in press) (2024)
Preliminary findings from the Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE I) Study: a Randomized Controlled Trial in Clinical Infectious Diseases (2024)
A speed limit on serial strain replacement from original antigenic sin in Proceedings of the National Academy of Sciences (2024)
Reduced effectiveness of repeat influenza vaccination: distinguishing among within-season waning, recent clinical infection, and subclinical infection in The Journal of Infectious Diseases (2024)