We study how the host adaptive immune response coevolves with pathogens, especially in ways relevant to epidemiological and evolutionary forecasting, vaccine design, and pathogen diversity. Our work is computational, and we collaborate closely with immunologists and epidemiologists.
Sarah, Ben Cowling, and Wey Wen Lim write in Nature Medicine that to extend vaccine supply, fractional dosing of mRNA vaccines should be considered. This was covered in STAT News, Nature, and the Financial Times.
July 6, 2021
Phil, Elena, and Sarah worked with Jaline Gerardin's group at Northwestern, along with epidemiologists from the CDC and Illinois Department of Public Health, to document severe COVID-19 testing disparities and low case ascertainment in Illinois.
June 10, 2021
The beneficial effects of vaccination on the evolution of seasonal influenza in American Naturalist (accepted) (2021)
Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality in Nature Medicine (2021)
Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases in Nature Communications (2021)