We study how the host adaptive immune response coevolves with pathogens, especially in ways relevant to epidemiological and evolutionary forecasting, vaccine design, and pathogen diversity. Our work is computational, and we collaborate closely with immunologists and epidemiologists.
Using theoretical models, we show that estimates of vaccine effectiveness can differ from a vaccine's true level of protection when vaccinated and unvaccinated populations have different distributions of pre-vaccination infection risk, highlighting the need to understand what immunological, behavioral, and environmental factors contribute to individuals' risk of infection.
Aug. 31, 2026
Congratulations to Alex, who was awarded an F31!
Aug. 24, 2026
Heterogeneity in pre-vaccination population immunity can contribute to variability in vaccine effectiveness estimates in medRxiv (2026)
Cross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune history in Nature Communications (2026)
Susceptible host dynamics explain pathogen resilience to perturbations in PNAS (2026)
Immune history shapes human antibody responses to H5N1 influenza viruses in Nature Medicine (2025)