We study how the host adaptive immune response coevolves with pathogens, especially in ways relevant to vaccine design and pathogen diversity. Our work is computational, and we collaborate closely with immunologists and epidemiologists.
Our paper in Nature Communications shows how immune memory shapes protection to influenza in adults and children. Bonuses: Estimation of imprinting effects, epidemic sizes, household transmission, & more!
April 10, 2019
Angsty germophobia and germophilia on display in this Nerdette podcast.
March 8, 2019
Age-specific differences in the dynamics of protective immunity to influenza in Nature Communications (2019)
Influenza virus vaccination elicits poorly adapted B cell responses in elderly individuals in Cell Host & Microbe (2019)
Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination in The Journal of Clinical Investigation (2018)
Repeated vaccination may protect children from influenza infection in JAMA Network Open (2018)